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Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation
Author(s) -
Maija Bry,
Riikka Kivelä,
Tanja Holopainen,
Andrey Anisimov,
Tuomas Tammela,
Jarkko Soronen,
Johanna M. U. Silvola,
Antti Saraste,
Michael Jeltsch,
Petra Korpisalo,
Peter Carmeliet,
Karl Lemström,
Masabumi Shibuya,
Seppo YläHerttuala,
Leena Alhonen,
Eero Mervaala,
Leif C. Andersson,
Juhani Knuuti,
Kari Alitalo
Publication year - 2010
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.110.957332
Subject(s) - medicine , angiogenesis , vascular endothelial growth factor , inflammation , vascular endothelial growth factor c , vascular endothelial growth factor b , genetically modified mouse , transgene , vascular endothelial growth factor a , growth factor , cancer research , vegf receptors , receptor , biology , biochemistry , gene
Vascular endothelial growth factor-B (VEGF-B) binds to VEGF receptor-1 and neuropilin-1 and is abundantly expressed in the heart, skeletal muscle, and brown fat. The biological function of VEGF-B is incompletely understood.

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