Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice | Zendy

Asish K. Ghosh | Zendy; William Bradham | Zendy; Linda A. Gleaves | Zendy; Bart De Taeye | Zendy; Sheila B. Murphy | Zendy; Joseph W. Covington | Zendy; Douglas E. Vaughan | Zendy

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Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice

Author(s) -

Asish K. Ghosh,

William Bradham,

Linda A. Gleaves,

Bart De Taeye,

Sheila B. Murphy,

Joseph W. Covington,

Douglas E. Vaughan

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.955245

Subject(s) - medicine , plasminogen activator inhibitor 1 , plasminogen activator , cardiac fibrosis , fibrosis , activator (genetics) , endocrinology , receptor

Elevated levels of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor of urokinase plasminogen activator and tissue plasminogen activator, are implicated in the pathogenesis of tissue fibrosis. Paradoxically, lack of PAI-1 in the heart is associated with the development of cardiac fibrosis in aged mice. However, the molecular basis of cardiac fibrosis in aged PAI-1-deficient mice is unknown. Here, we investigated the molecular and cellular bases of myocardial fibrosis.

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