MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning | Zendy

Chunmei Cao | Zendy; Yan Zhang | Zendy; Noah Weisleder | Zendy; Christopher Ferrante | Zendy; Xianhua Wang | Zendy; Fengxiang Lv | Zendy; Yi Zhang | Zendy; Ruisheng Song | Zendy; Moonsun Hwang | Zendy; Jin Li | Zendy; Jiaojiao Guo | Zendy; Wei Peng | Zendy; Geng Li | Zendy; Miyuki Nishi | Zendy; Hiroshi Takeshima | Zendy; Jianjie Ma | Zendy; RuiPing Xiao | Zendy

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MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning

Author(s) -

Chunmei Cao,

Yan Zhang,

Noah Weisleder,

Christopher Ferrante,

Xianhua Wang,

Fengxiang Lv,

Yi Zhang,

Ruisheng Song,

Moonsun Hwang,

Jin Li,

Jiaojiao Guo,

Wei Peng,

Geng Li,

Miyuki Nishi,

Hiroshi Takeshima,

Jianjie Ma,

RuiPing Xiao

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.954628

Subject(s) - medicine , ischemic preconditioning , ischemia , reperfusion injury , cardioprotection , protein kinase b , downregulation and upregulation , pi3k/akt/mtor pathway , hypoxia (environmental) , cardiology , signal transduction , microbiology and biotechnology , biology , biochemistry , chemistry , organic chemistry , oxygen , gene

Ischemic heart disease is the greatest cause of death in Western countries. The deleterious effects of cardiac ischemia are ameliorated by ischemic preconditioning (IPC), in which transient ischemia protects against subsequent severe ischemia/reperfusion injury. IPC activates multiple signaling pathways, including the reperfusion injury salvage kinase pathway (mainly PI3K-Akt-glycogen synthase kinase-3beta [GSK3beta] and ERK1/2) and the survivor activating factor enhancement pathway involving activation of the JAK-STAT3 axis. Nevertheless, the fundamental mechanism underlying IPC is poorly understood.

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