C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice | Zendy

Erdenechimeg Shagdarsuren | Zendy; Kiril Bidzhekov | Zendy; Sebastian F. Mause | Zendy; Sakine Simsekyilmaz | Zendy; Thomas Polakowski | Zendy; Heiko Hawlisch | Zendy; J. Engelbert Gessner | Zendy; Alma Zernecke | Zendy; Christian Weber | Zendy

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C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice

Author(s) -

Erdenechimeg Shagdarsuren,

Kiril Bidzhekov,

Sebastian F. Mause,

Sakine Simsekyilmaz,

Thomas Polakowski,

Heiko Hawlisch,

J. Engelbert Gessner,

Alma Zernecke,

Christian Weber

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.954370

Subject(s) - neointima , medicine , vascular smooth muscle , neointimal hyperplasia , c5a receptor , receptor , proinflammatory cytokine , endocrinology , endothelial stem cell , inflammation , pathology , immunology , antibody , complement system , biology , in vitro , biochemistry , restenosis , smooth muscle , stent

Receptor binding of complement C5a leads to proinflammatory activation of many cell types, but the role of receptor-mediated action during arterial remodeling after injury has not been studied. In the present study, we examined the contribution of the C5a receptor (C5aR) to neointima formation in apolipoprotein E-deficient mice employing a C5aR antagonist (C5aRA) and a C5aR-blocking monoclonal antibody.

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