Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells | Zendy

Kenichiro Koda | Zendy; Mariselis Salazar-Rodriguez | Zendy; Federico Corti | Zendy; Noel YanKi Chan | Zendy; Racha Estephan | Zendy; Randi B. Silver | Zendy; Daria MochlyRosen | Zendy; Roberto Levi | Zendy

Open Access

Aldehyde Dehydrogenase Activation Prevents Reperfusion Arrhythmias by Inhibiting Local Renin Release From Cardiac Mast Cells

Author(s) -

Kenichiro Koda,

Mariselis Salazar-Rodriguez,

Federico Corti,

Noel YanKi Chan,

Racha Estephan,

Randi B. Silver,

Daria MochlyRosen,

Roberto Levi

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.952481

Subject(s) - medicine , degranulation , renin–angiotensin system , cardioprotection , pharmacology , ischemic preconditioning , adenosine , protein kinase c , ischemia , endocrinology , receptor , signal transduction , biology , microbiology and biotechnology , blood pressure

Renin released by ischemia/reperfusion from cardiac mast cells activates a local renin-angiotensin system (RAS). This exacerbates norepinephrine release and reperfusion arrhythmias (ventricular tachycardia and fibrillation), making RAS a new therapeutic target in myocardial ischemia.

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