Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia | Zendy

Andrea Caporali | Zendy; Marco Meloni | Zendy; Christine Völlenkle | Zendy; Désirée Bonci | Zendy; Graciela B. SalaNewby | Zendy; Roberta Addis | Zendy; Gaia Spinetti | Zendy; Sergio Losa | Zendy; Rachel Masson | Zendy; Andrew H. Baker | Zendy; Reuven Agami | Zendy; Carlos le Sage | Zendy; Gianluigi Condorelli | Zendy; Paolo Madeddu | Zendy; Fabio Martelli | Zendy; Costanza Emanueli | Zendy

Open Access

Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia

Author(s) -

Andrea Caporali,

Marco Meloni,

Christine Völlenkle,

Désirée Bonci,

Graciela B. SalaNewby,

Roberta Addis,

Gaia Spinetti,

Sergio Losa,

Rachel Masson,

Andrew H. Baker,

Reuven Agami,

Carlos le Sage,

Gianluigi Condorelli,

Paolo Madeddu,

Fabio Martelli,

Costanza Emanueli

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.952325

Subject(s) - medicine , angiogenesis , ischemia , diabetes mellitus , limb ischemia , microrna , endothelial dysfunction , cardiology , endocrinology , gene , biochemistry , chemistry

Diabetes mellitus impairs endothelial cell (EC) function and postischemic reparative neovascularization by molecular mechanisms that are not fully understood. microRNAs negatively regulate the expression of target genes mainly by interaction in their 3' untranslated region.

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