Open AccessIntrinsic Coagulation Activation and the Risk of Arterial Thrombosis in Young Women
Author(s) -
Bob Siegerink,
José W.P. GoversRiemslag,
F.R. Rosendaal,
Hugo Ten Cate,
Ale Algra
Publication year - 2010
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.110.943738
Subject(s) - medicine , thrombosis , coagulation , cardiology
Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred by increased activation of intrinsic coagulation proteins in young women and the effect of oral contraceptive use on this association.
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