Pulmonary and Systemic Vascular Dysfunction in Young Offspring of Mothers With Preeclampsia | Zendy

PierreYves Jayet | Zendy; Stefano F. Rimoldi | Zendy; Thomas Stüber | Zendy; Carlos Salinas Salmón | Zendy; Damian Hutter | Zendy; Emrush Rexhaj | Zendy; Sébastien Thalmann | Zendy; Marcos Schwab | Zendy; Pierre Turini | Zendy; Céline Sartori-Cucchia | Zendy; Pascal Nicod | Zendy; Mercedes Villena | Zendy; Yves Allemann | Zendy; Urs Scherrer | Zendy; Cláudio Sartori | Zendy

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Pulmonary and Systemic Vascular Dysfunction in Young Offspring of Mothers With Preeclampsia

Author(s) -

PierreYves Jayet,

Stefano F. Rimoldi,

Thomas Stüber,

Carlos Salinas Salmón,

Damian Hutter,

Emrush Rexhaj,

Sébastien Thalmann,

Marcos Schwab,

Pierre Turini,

Céline Sartori-Cucchia,

Pascal Nicod,

Mercedes Villena,

Yves Allemann,

Urs Scherrer,

Cláudio Sartori

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.941203

Subject(s) - offspring , medicine , preeclampsia , cardiology , pulmonary artery , pregnancy , brachial artery , placenta , endocrinology , endothelial dysfunction , physiology , blood pressure , fetus , genetics , biology

Adverse events in utero may predispose to cardiovascular disease in adulthood. The underlying mechanisms are unknown. During preeclampsia, vasculotoxic factors are released into the maternal circulation by the diseased placenta. We speculated that these factors pass the placental barrier and leave a defect in the circulation of the offspring that predisposes to a pathological response later in life. The hypoxia associated with high-altitude exposure is expected to facilitate the detection of this problem.

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