Ca 2+ -Related Signaling and Protein Phosphorylation Abnormalities Play Central Roles in a New Experimental Model of Electrical Storm | Zendy

Yukiomi Tsuji | Zendy; Mayumi Hojo | Zendy; Niels Voigt | Zendy; Ali ElArmouche | Zendy; Yasuya Inden | Zendy; Toyoaki Murohara | Zendy; Dobromir Dobrev | Zendy; Stanley Nattel | Zendy; Itsuo Kodama | Zendy; Kaichiro Kamiya | Zendy

Open Access

Ca ²⁺ -Related Signaling and Protein Phosphorylation Abnormalities Play Central Roles in a New Experimental Model of Electrical Storm

Author(s) -

Yukiomi Tsuji,

Mayumi Hojo,

Niels Voigt,

Ali ElArmouche,

Yasuya Inden,

Toyoaki Murohara,

Dobromir Dobrev,

Stanley Nattel,

Itsuo Kodama,

Kaichiro Kamiya

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.016683

Subject(s) - medicine , hyperphosphorylation , ventricular fibrillation , ryanodine receptor , defibrillation , endocrinology , ventricular tachycardia , cardiology , dephosphorylation , fibrillation , phosphorylation , phospholamban , phosphatase , calcium , biology , atrial fibrillation , microbiology and biotechnology

Electrical storm (ES), characterized by recurrent ventricular tachycardia/fibrillation, typically occurs in implantable cardioverter-defibrillator patients and adversely affects prognosis. However, the underlying molecular basis is poorly understood. In the present study, we report a new experimental model featuring repetitive episodes of implantable cardioverter-defibrillator firing for recurrent ventricular fibrillation (VF), in which we assessed involvement of Ca(2+)-related protein alterations in ES.

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