Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion | Zendy

Satoshi Itoh | Zendy; Naoyuki Kimura | Zendy; Robert C. Axtell | Zendy; Jeffrey B. Velotta | Zendy; Yongquan Gong | Zendy; Xi Wang | Zendy; Naoki Kajiwara | Zendy; Aya Nambu | Zendy; Eri Shimura | Zendy; Hideo Adachi | Zendy; Yoichiro Iwakura | Zendy; Hirohisa Saito | Zendy; Ko Okumura | Zendy; Katsuko Sudo | Zendy; Lawrence Steinman | Zendy; Robert C. Robbins | Zendy; Susumu Nakae | Zendy; Michael P. Fischbein | Zendy

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Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion

Author(s) -

Satoshi Itoh,

Naoyuki Kimura,

Robert C. Axtell,

Jeffrey B. Velotta,

Yongquan Gong,

Xi Wang,

Naoki Kajiwara,

Aya Nambu,

Eri Shimura,

Hideo Adachi,

Yoichiro Iwakura,

Hirohisa Saito,

Ko Okumura,

Katsuko Sudo,

Lawrence Steinman,

Robert C. Robbins,

Susumu Nakae,

Michael P. Fischbein

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.014852

Subject(s) - immunology , medicine , transplantation , cd8 , il 2 receptor , t cell , cytokine , interleukin 21 , chemokine , pathogenesis , transplant rejection , inflammation , immune system

Interleukin-17 (IL-17), which is predominantly produced by T helper 17 cells distinct from T helper 1 or T helper 2 cells, participates in the pathogenesis of infectious, autoimmune, and allergic disorders. However, the precise role in allograft rejection remains uncertain. In the present study, we investigated the role of IL-17 in acute allograft rejection using IL-17-deficient mice.

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