Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus | Zendy

Sherene M. Shenouda | Zendy; Michael E. Widlansky | Zendy; Kai Chen | Zendy; Guoquan Xu | Zendy; Monika Holbrook | Zendy; Corey E. Tabit | Zendy; Naomi M. Hamburg | Zendy; Alissa A. Frame | Zendy; Tara L. Caiano | Zendy; Matthew A. Kluge | Zendy; MaiAnn Duess | Zendy; Aaron Levit | Zendy; Brian Kim | Zendy; Mor-Li Hartman | Zendy; Lija Joseph | Zendy; Orian S. Shirihai | Zendy; Joseph A. Vita | Zendy

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Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus

Author(s) -

Sherene M. Shenouda,

Michael E. Widlansky,

Kai Chen,

Guoquan Xu,

Monika Holbrook,

Corey E. Tabit,

Naomi M. Hamburg,

Alissa A. Frame,

Tara L. Caiano,

Matthew A. Kluge,

MaiAnn Duess,

Aaron Levit,

Brian Kim,

Mor-Li Hartman,

Lija Joseph,

Orian S. Shirihai,

Joseph A. Vita

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.014506

Subject(s) - medicine , diabetes mellitus , endothelial dysfunction , cardiology , endocrinology

Endothelial dysfunction contributes to the development of atherosclerosis in patients with diabetes mellitus, but the mechanisms of endothelial dysfunction in this setting are incompletely understood. Recent studies have shown altered mitochondrial dynamics in diabetes mellitus with increased mitochondrial fission and production of reactive oxygen species. We investigated the contribution of altered dynamics to endothelial dysfunction in diabetes mellitus.

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