Pravastatin Reduces Marfan Aortic Dilation | Zendy

Darren McLoughlin | Zendy; Jonathan McGuinness | Zendy; John Byrne | Zendy; E. Terzo | Zendy; Vilhelmiina Huuskonen | Zendy; Hester McAllister | Zendy; Alexander Black | Zendy; Sinéad Kearney | Zendy; Elaine W. Kay | Zendy; Arnold D. Hill | Zendy; Harry C. Dietz | Zendy; Janice Redmond | Zendy

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Pravastatin Reduces Marfan Aortic Dilation

Author(s) -

Darren McLoughlin,

Jonathan McGuinness,

John Byrne,

E. Terzo,

Vilhelmiina Huuskonen,

Hester McAllister,

Alexander Black,

Sinéad Kearney,

Elaine W. Kay,

Arnold D. Hill,

Harry C. Dietz,

Janice Redmond

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.012187

Subject(s) - medicine , marfan syndrome , pravastatin , losartan , cardiology , aorta , endocrinology , angiotensin ii , blood pressure , cholesterol

The sequelae of aortic root dilation are the lethal consequences of Marfan syndrome. The root dilation is attributable to an imbalance between deposition of matrix elements and metalloproteinases in the aortic medial layer as a result of excessive transforming growth factor-beta signaling. This study examined the efficacy and mechanism of statins in attenuating aortic root dilation in Marfan syndrome and compared effects to the other main proposed preventative agent, losartan.

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