An Open Sarcolemmal Adenosine Triphosphate-Sensitive Potassium Channel Is Necessary for Detrimental Myocyte Swelling Secondary to Stress | Zendy

Angela D. Sellitto | Zendy; Ashraf AlDadah | Zendy; Richard B. Schuessler | Zendy; Colin G. Nichols | Zendy; Jennifer S. Lawton | Zendy

Open Access

An Open Sarcolemmal Adenosine Triphosphate-Sensitive Potassium Channel Is Necessary for Detrimental Myocyte Swelling Secondary to Stress

Author(s) -

Angela D. Sellitto,

Ashraf AlDadah,

Richard B. Schuessler,

Colin G. Nichols,

Jennifer S. Lawton

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.012039

Subject(s) - myocyte , contractility , medicine , potassium channel , endocrinology , adenosine triphosphate , pharmacology

Stress (exposure to hyperkalemic cardioplegia, metabolic inhibition, or osmotic) results in significant myocyte swelling and reduced contractility. In contrast to wild-type mice, these detrimental consequences are not observed in mice lacking the Kir6.2 subunit of the sarcolemmal ATP-sensitive potassium (sK(ATP)) channel after exposure to hyperkalemic cardioplegia. The hypothesis for this study was that an open sK(ATP) channel (Kir6.2 and SUR2A subunits) is necessary for detrimental myocyte swelling to occur in response to stress.

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