Pharmacologic Suppression of Hepatic ATP-Binding Cassette Transporter 1 Activity in Mice Reduces High-Density Lipoprotein Cholesterol Levels but Promotes Reverse Cholesterol Transport | Zendy

Shigenori Yamamoto | Zendy; Hiroyuki Tanigawa | Zendy; Xiaoyu Li | Zendy; Yohei Komaru | Zendy; Jeffrey T. Billheimer | Zendy; Daniel J. Rader | Zendy

Open Access

Pharmacologic Suppression of Hepatic ATP-Binding Cassette Transporter 1 Activity in Mice Reduces High-Density Lipoprotein Cholesterol Levels but Promotes Reverse Cholesterol Transport

Author(s) -

Shigenori Yamamoto,

Hiroyuki Tanigawa,

Xiaoyu Li,

Yohei Komaru,

Jeffrey T. Billheimer,

Daniel J. Rader

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.009704

Subject(s) - probucol , abca1 , reverse cholesterol transport , cholesterol , medicine , endocrinology , high density lipoprotein , excretion , lipoprotein , knockout mouse , pharmacology , chemistry , transporter , receptor , biochemistry , gene

The role of hepatic ATP-binding cassette transporter 1 (ABCA1) in maintaining plasma high density lipoprotein cholesterol (HDL-C) levels is well established, but its role in reverse cholesterol transport (RCT) is unclear. Probucol is a compound that reduces HDL-C levels but also reduces atherosclerosis in animal models and xanthomas in humans. The aim of the present study was to test the hypothesis that probucol inhibits hepatic ABCA1 activity, thereby reducing HDL-C levels but promoting RCT from macrophages.

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