Computational Protein Design to Reengineer Stromal Cell–Derived Factor-1α Generates an Effective and Translatable Angiogenic Polypeptide Analog | Zendy

William Hiesinger | Zendy; Jose Manuel PerezAguilar | Zendy; Pavan Atluri | Zendy; Nicole A. Marotta | Zendy; John R. Frederick | Zendy; J. Raymond Fitzpatrick | Zendy; Ryan C. McCormick | Zendy; Jeffrey R. Muenzer | Zendy; Elaine Yang | Zendy; Rebecca D. Levit | Zendy; Lijun Yuan | Zendy; John W. MacArthur | Zendy; Jeffery G. Saven | Zendy; Y. Joseph Woo | Zendy

Open Access

Computational Protein Design to Reengineer Stromal Cell–Derived Factor-1α Generates an Effective and Translatable Angiogenic Polypeptide Analog

Author(s) -

William Hiesinger,

Jose Manuel PerezAguilar,

Pavan Atluri,

Nicole A. Marotta,

John R. Frederick,

J. Raymond Fitzpatrick,

Ryan C. McCormick,

Jeffrey R. Muenzer,

Elaine Yang,

Rebecca D. Levit,

Lijun Yuan,

John W. MacArthur,

Jeffery G. Saven,

Y. Joseph Woo

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.009431

Subject(s) - stromal cell , protein kinase b , medicine , progenitor cell , angiogenesis , growth factor , stem cell , phosphorylation , microbiology and biotechnology , cancer research , receptor , biology

Experimentally, exogenous administration of recombinant stromal cell-derived factor-1α (SDF) enhances neovasculogenesis and cardiac function after myocardial infarction. Smaller analogs of SDF may provide translational advantages including enhanced stability and function, ease of synthesis, lower cost, and potential modulated delivery via engineered biomaterials. In this study, computational protein design was used to create a more efficient evolution of the native SDF protein.

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