Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion | Zendy

Chenell Donadee | Zendy; Nicolaas J.H. Raat | Zendy; Tamir Kanias | Zendy; Jesús Tejero | Zendy; Janet Lee | Zendy; Eric E. Kelley | Zendy; Xuejun Zhao | Zendy; Chen Liu | Zendy; Hannah Reynolds | Zendy; Ivan Azarov | Zendy; Sheila Frizzell | Zendy; E. Michael Meyer | Zendy; Albert D. Donnenberg | Zendy; Lirong Qu | Zendy; Darrel Triulzi | Zendy; Daniel B. Kim–Shapiro | Zendy; Mark T. Gladwin | Zendy

Open Access

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

Author(s) -

Chenell Donadee,

Nicolaas J.H. Raat,

Tamir Kanias,

Jesús Tejero,

Janet Lee,

Eric E. Kelley,

Xuejun Zhao,

Chen Liu,

Hannah Reynolds,

Ivan Azarov,

Sheila Frizzell,

E. Michael Meyer,

Albert D. Donnenberg,

Lirong Qu,

Darrel Triulzi,

Daniel B. Kim–Shapiro,

Mark T. Gladwin

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.008698

Subject(s) - hemolysis , hemoglobin , nitric oxide , red blood cell , vasoconstriction , red cell , vasodilation , medicine , methemoglobin , lesion , endothelium , oxidative stress , pharmacology , biochemistry , chemistry , immunology , pathology

Intravascular red cell hemolysis impairs nitric oxide (NO)-redox homeostasis, producing endothelial dysfunction, platelet activation, and vasculopathy. Red blood cell storage under standard conditions results in reduced integrity of the erythrocyte membrane, with formation of exocytic microvesicles or microparticles and hemolysis, which we hypothesized could impair vascular function and contribute to the putative storage lesion of banked blood.

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