Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a | Zendy

Wei Wu | Zendy; Han Xiao | Zendy; Andrés LagunaFernandez | Zendy; Guadalupe Villarreal | Zendy; Kuei-Chun Wang | Zendy; Greg G. Geary | Zendy; Yuzhi Zhang | Zendy; Wei-Chi Wang | Zendy; HsienDa Huang | Zendy; Jing Zhou | Zendy; Yi-Shuan Li | Zendy; Shu Chien | Zendy; Guillermo Garcı́a-Cardeña | Zendy; John Y.J. Shyy | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

Author(s) -

Wei Wu,

Han Xiao,

Andrés LagunaFernandez,

Guadalupe Villarreal,

Kuei-Chun Wang,

Greg G. Geary,

Yuzhi Zhang,

Wei-Chi Wang,

HsienDa Huang,

Jing Zhou,

Yi-Shuan Li,

Shu Chien,

Guillermo Garcı́a-Cardeña,

John Y.J. Shyy

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.005108

Subject(s) - klf2 , umbilical vein , gene knockdown , microbiology and biotechnology , nitric oxide synthase , endothelium , downregulation and upregulation , medicine , biology , nitric oxide , biochemistry , gene , in vitro

Upregulated by atheroprotective flow, the transcription factor Krüppel-like factor 2 (KLF2) is crucial for maintaining endothelial function. MicroRNAs (miRNAs) are noncoding small RNAs that regulate gene expression at the posttranscriptional level. We examined the role of miRNAs, particularly miR-92a, in the atheroprotective flow-regulated KLF2.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research