Casein Kinase-2α1 Induces Hypertrophic Response by Phosphorylation of Histone Deacetylase 2 S394 and its Activation in the Heart | Zendy

Gwang Hyeon Eom | Zendy; Young Kuk Cho | Zendy; JeongHyeon Ko | Zendy; Sera Shin | Zendy; Nakwon Choe | Zendy; Yoojung Kim | Zendy; Hosouk Joung | Zendy; Hyung-Seok Kim | Zendy; Kwang Il Nam | Zendy; Hae Jin Kee | Zendy; Hyun Kook | Zendy

Open Access

Casein Kinase-2α1 Induces Hypertrophic Response by Phosphorylation of Histone Deacetylase 2 S394 and its Activation in the Heart

Author(s) -

Gwang Hyeon Eom,

Young Kuk Cho,

JeongHyeon Ko,

Sera Shin,

Nakwon Choe,

Yoojung Kim,

Hosouk Joung,

Hyung-Seok Kim,

Kwang Il Nam,

Hae Jin Kee,

Hyun Kook

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.003665

Subject(s) - histone deacetylase 2 , muscle hypertrophy , phosphorylation , trichostatin a , medicine , endocrinology , casein kinase 2 , transgene , kinase , histone deacetylase , biology , protein kinase a , histone , microbiology and biotechnology , biochemistry , mitogen activated protein kinase kinase , gene

Cardiac hypertrophy is characterized by transcriptional reprogramming of fetal gene expression, and histone deacetylases (HDACs) are tightly linked to the regulation of those genes. We previously demonstrated that activation of HDAC2, 1 of the class I HDACs, mediates hypertrophy. Here, we show that casein kinase-2α1 (CK2α1)-dependent phosphorylation of HDAC2 S394 is required for the development of cardiac hypertrophy.

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