Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion | Zendy

Marc Liesa | Zendy; Ivan Luptak | Zendy; Fuzhong Qin | Zendy; Brigham B. Hyde | Zendy; Ergün Sahin | Zendy; Deborah A. Siwik | Zendy; Zhengkun Zhu | Zendy; David R. Pimentel | Zendy; X. Julia Xu | Zendy; Neil B. Ruderman | Zendy; Karl Huffman | Zendy; Susan R. Doctrow | Zendy; Lauren Richey | Zendy; Wilson S. Colucci | Zendy; Orian S. Shirihai | Zendy

Open Access

Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion

Author(s) -

Marc Liesa,

Ivan Luptak,

Fuzhong Qin,

Brigham B. Hyde,

Ergün Sahin,

Deborah A. Siwik,

Zhengkun Zhu,

David R. Pimentel,

X. Julia Xu,

Neil B. Ruderman,

Karl Huffman,

Susan R. Doctrow,

Lauren Richey,

Wilson S. Colucci,

Orian S. Shirihai

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.003418

Subject(s) - mitochondrion , oxidative stress , ischemia , oxidative phosphorylation , reperfusion injury , atp binding cassette transporter , biology , medicine , pharmacology , microbiology and biotechnology , endocrinology , biochemistry , transporter , gene

Oxidative stress and mitochondrial dysfunction are central mediators of cardiac dysfunction after ischemia/reperfusion. ATP binding cassette mitochondrial erythroid (ABC-me; ABCB10; mABC2) is a mitochondrial transporter highly induced during erythroid differentiation and predominantly expressed in bone marrow, liver, and heart. Until now, ABC-me function in heart was unknown. Several lines of evidence demonstrate that the yeast ortholog of ABC-me protects against increased oxidative stress. Therefore, ABC-me is a potential modulator of the outcome of ischemia/reperfusion in the heart.

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