Open AccessPredictors of Bleeding and Time Dependence of Association of Bleeding With Mortality
Author(s) -
Willibald Hochholzer,
Stephen D. Wiviott,
Elliott M. Antman,
Charles F. Contant,
Jianping Guo,
Robert P. Giugliano,
Anthony J. Dalby,
Gilles Montalescot,
Eugene Braunwald
Publication year - 2011
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.110.002683
Subject(s) - medicine , prasugrel , hazard ratio , timi , myocardial infarction , cardiology , percutaneous coronary intervention , proportional hazards model , acute coronary syndrome , confidence interval
The balance between benefit (ischemia protection) and risk (bleeding) is a key consideration in choosing the intensity of antiplatelet therapy for patients with acute coronary syndromes. The goals of this analysis were to identify baseline characteristics that independently predict bleeding and to determine how bleeding events impact the subsequent mortality in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel--Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38).