MicroRNA-100 Regulates Neovascularization by Suppression of Mammalian Target of Rapamycin in Endothelial and Vascular Smooth Muscle Cells | Zendy

Sebastian Grundmann | Zendy; Felix Patricius Hans | Zendy; Sheena Kinniry | Zendy; Jennifer Heinke | Zendy; Thomas Helbing | Zendy; Franziska Bluhm | Zendy; Joost P. G. Sluijter | Zendy; Imo E. Hoefer | Zendy; Gerard Pasterkamp | Zendy; Christoph Bode | Zendy; Martin Moser | Zendy

Open Access

MicroRNA-100 Regulates Neovascularization by Suppression of Mammalian Target of Rapamycin in Endothelial and Vascular Smooth Muscle Cells

Author(s) -

Sebastian Grundmann,

Felix Patricius Hans,

Sheena Kinniry,

Jennifer Heinke,

Thomas Helbing,

Franziska Bluhm,

Joost P. G. Sluijter,

Imo E. Hoefer,

Gerard Pasterkamp,

Christoph Bode,

Martin Moser

Publication year - 2011

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.110.000323

Subject(s) - pi3k/akt/mtor pathway , angiogenesis , microbiology and biotechnology , microrna , vascular smooth muscle , biology , mural cell , medicine , cancer research , signal transduction , endocrinology , gene , biochemistry , smooth muscle

The adaptive growth of blood vessels is an important protective mechanism in cardiovascular disease. However, the underlying regulatory mechanisms of this process are only partly understood. Recently, small endogenous RNAs (microRNAs [miRNAs]) were found to play an important role in embryonic and postnatal vascular development. Here, we used miRNA transcriptome analysis after induction of hind-limb ischemia in mice to screen for miRNAs involved in adaptive blood vessel growth following arterial occlusion.

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