Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy | Zendy

Khalid Abozguia | Zendy; Perry Elliott | Zendy; William J. McKenna | Zendy; Thanh Trung Phan | Zendy; Ganesh Nallur-Shivu | Zendy; Irfan Ahmed | Zendy; Abdul Maher | Zendy; Kulvinder Kaur | Zendy; Jenny C. Taylor | Zendy; A Henning | Zendy; Houman Ashrafian | Zendy; Hugh Watkins | Zendy; Michael Frenneaux | Zendy

Open Access

Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy

Author(s) -

Khalid Abozguia,

Perry Elliott,

William J. McKenna,

Thanh Trung Phan,

Ganesh Nallur-Shivu,

Irfan Ahmed,

Abdul Maher,

Kulvinder Kaur,

Jenny C. Taylor,

A Henning,

Houman Ashrafian,

Hugh Watkins,

Michael Frenneaux

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.934059

Subject(s) - medicine , phosphocreatine , hypertrophic cardiomyopathy , cardiology , cardiomyopathy , diastole , heart failure , heart rate , placebo , endocrinology , energy metabolism , blood pressure , alternative medicine , pathology

Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic cardiomyopathy remains unproven. We hypothesized that the metabolic modulator perhexiline would ameliorate myocardial energy deficiency and thereby improve diastolic function and exercise capacity.

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