Mobilized Human Hematopoietic Stem/Progenitor Cells Promote Kidney Repair After Ischemia/Reperfusion Injury | Zendy

Bing Li | Zendy; Amy Cohen | Zendy; Thomas E. Hudson | Zendy; Delara Motlagh | Zendy; David L. Amrani | Zendy; Jeremy S. Duffield | Zendy

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Mobilized Human Hematopoietic Stem/Progenitor Cells Promote Kidney Repair After Ischemia/Reperfusion Injury

Author(s) -

Bing Li,

Amy Cohen,

Thomas E. Hudson,

Delara Motlagh,

David L. Amrani,

Jeremy S. Duffield

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.928796

Subject(s) - progenitor cell , medicine , paracrine signalling , renal stem cell , regeneration (biology) , cd34 , stem cell , kidney , haematopoiesis , acute kidney injury , endothelial stem cell , microbiology and biotechnology , cancer research , pathology , immunology , biology , receptor , biochemistry , in vitro

Understanding the mechanisms of repair and regeneration of the kidney after injury is of great interest because there are currently no therapies that promote repair, and kidneys frequently do not repair adequately. We studied the capacity of human CD34(+) hematopoietic stem/progenitor cells (HSPCs) to promote kidney repair and regeneration using an established ischemia/reperfusion injury model in mice, with particular focus on the microvasculature.

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