Preoperative Atorvastatin Treatment in CABG Patients Rapidly Improves Vein Graft Redox State by Inhibition of Rac1 and NADPH-Oxidase Activity | Zendy

Charalambos Antoniades | Zendy; Constantinos Bakogiannis | Zendy; Dimitris Tousoulis | Zendy; Svetlana Reilly | Zendy; Meihua Zhang | Zendy; Andreas Paschalis | Zendy; Alexios S. Antonopoulos | Zendy; Michael Demosthenous | Zendy; Antigoni Miliou | Zendy; Costas Psarros | Zendy; Kyriakoula Marinou | Zendy; Nikolaos Sfyras | Zendy; George Economopoulos | Zendy; Barbara Casadei | Zendy; Keith M. Chan | Zendy; Christodoulos Stefanadis | Zendy

Open Access

Preoperative Atorvastatin Treatment in CABG Patients Rapidly Improves Vein Graft Redox State by Inhibition of Rac1 and NADPH-Oxidase Activity

Author(s) -

Charalambos Antoniades,

Constantinos Bakogiannis,

Dimitris Tousoulis,

Svetlana Reilly,

Meihua Zhang,

Andreas Paschalis,

Alexios S. Antonopoulos,

Michael Demosthenous,

Antigoni Miliou,

Costas Psarros,

Kyriakoula Marinou,

Nikolaos Sfyras,

George Economopoulos,

Barbara Casadei,

Keith M. Chan,

Christodoulos Stefanadis

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.927376

Subject(s) - atorvastatin , medicine , statin , nadph oxidase , pharmacology , endocrinology , gastroenterology , oxidative stress

Statins improve clinical outcome of patients with atherosclerosis, but their perioperative role in patients undergoing coronary artery bypass grafting (CABG) is unclear. We hypothesized that short-term treatment with atorvastatin before CABG would improve the redox state in saphenous vein grafts (SVGs), independently of low-density lipoprotein cholesterol (LDL)-lowering.

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