Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E–Deficient Mice | Zendy

Emily Smith | Zendy; Konkal-Matt R Prasad | Zendy; Matthew Butcher | Zendy; Anca D. Dobrian | Zendy; Jay K. Kolls | Zendy; Klaus Ley | Zendy; Elena Galkina | Zendy

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Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E–Deficient Mice

Author(s) -

Emily Smith,

Konkal-Matt R Prasad,

Matthew Butcher,

Anca D. Dobrian,

Jay K. Kolls,

Klaus Ley,

Elena Galkina

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.924886

Subject(s) - interleukin 17 , cxcl1 , apolipoprotein e , medicine , immune system , endocrinology , interleukin , spleen , monocyte , immunology , cytokine , chemokine , disease

T cells play an important role during the immune response that accompanies atherosclerosis. To date, the role for interleukin (IL)-17A in atherogenesis is not well defined. Here, we tested the hypothesis that atherosclerosis-prone conditions induce the differentiation of IL-17A-producing T cells, which in turn promote atherosclerosis.

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