Chromosome 9p21 Variant Predicts Mortality After Coronary Artery Bypass Graft Surgery | Zendy

Jochen D. Muehlschlegel | Zendy; Kuang-Yu Liu | Zendy; Tjörvi E. Perry | Zendy; Amanda A. Fox | Zendy; Charles D. Collard | Zendy; Stanton K. Shernan | Zendy; Simon C. Body | Zendy

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Chromosome 9p21 Variant Predicts Mortality After Coronary Artery Bypass Graft Surgery

Author(s) -

Jochen D. Muehlschlegel,

Kuang-Yu Liu,

Tjörvi E. Perry,

Amanda A. Fox,

Charles D. Collard,

Stanton K. Shernan,

Simon C. Body

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.924233

Subject(s) - medicine , hazard ratio , perioperative , euroscore , myocardial infarction , cardiology , coronary artery bypass surgery , proportional hazards model , odds ratio , bypass surgery , coronary artery disease , confidence interval , surgery , cardiac surgery , artery

Recent genome-wide association studies have identified several chromosome 9p21 single nucleotide polymorphisms associated with coronary artery disease and myocardial infarction in nonsurgical populations. We have recently demonstrated an independent association between these 9p21 variants and perioperative myocardial injury after isolated primary coronary artery bypass graft (CABG) surgery. This study investigated the association of a 9p21 variant with mortality in patients after CABG surgery and its prognostic value to improve the EuroSCORE.

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