Mechanisms Underlying the Lack of Effect of Implantable Cardioverter-Defibrillator Therapy on Mortality in High-Risk Patients With Recent Myocardial Infarction | Zendy

Paul Dorian | Zendy; Stefan H. Hohnloser | Zendy; Kevin E. Thorpe | Zendy; Robin S. Roberts | Zendy; KarlHeinz Kück | Zendy; Michael Gent | Zendy; Stuart J. Connolly | Zendy

Open Access

Mechanisms Underlying the Lack of Effect of Implantable Cardioverter-Defibrillator Therapy on Mortality in High-Risk Patients With Recent Myocardial Infarction

Author(s) -

Paul Dorian,

Stefan H. Hohnloser,

Kevin E. Thorpe,

Robin S. Roberts,

KarlHeinz Kück,

Michael Gent,

Stuart J. Connolly

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.924225

Subject(s) - medicine , myocardial infarction , hazard ratio , cardiology , implantable cardioverter defibrillator , defibrillation , ejection fraction , confidence interval , sudden cardiac death , randomized controlled trial , sudden death , heart failure

although implantable cardioverter-defibrillators (ICDs) lower mortality in stable patients with low ejection fraction late after myocardial infarction, randomized trials of ICD versus control subjects implanted early after myocardial infarction do not show mortality benefit. Our objective was to investigate possible mechanisms underlying the lack of mortality benefit in the Defibrillation in Acute Myocardial Infarction Trial (DINAMIT).

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