Chymase Inhibition Prevents Fibronectin and Myofibrillar Loss and Improves Cardiomyocyte Function and LV Torsion Angle in Dogs With Isolated Mitral Regurgitation | Zendy

Betty Pat | Zendy; Yuanwen Chen | Zendy; Cheryl R. Killingsworth | Zendy; James D. Gladden | Zendy; Ke Shi | Zendy; Junying Zheng | Zendy; Pamela C. Powell | Zendy; Greg Walcott | Zendy; Mustafa I. Ahmed | Zendy; Himanshu Gupta | Zendy; Ravi Desai | Zendy; ChihChang Wei | Zendy; Naoki Hase | Zendy; Tsunefumi Kobayashi | Zendy; Abdelkarim Sabri | Zendy; Henk Granzier | Zendy; Thomas S. Denney | Zendy; Michael Tillson | Zendy; A. Ray Dillon | Zendy; Ahsan Husain | Zendy; Louis J. Dell’Italia | Zendy

Open Access

Chymase Inhibition Prevents Fibronectin and Myofibrillar Loss and Improves Cardiomyocyte Function and LV Torsion Angle in Dogs With Isolated Mitral Regurgitation

Author(s) -

Betty Pat,

Yuanwen Chen,

Cheryl R. Killingsworth,

James D. Gladden,

Ke Shi,

Junying Zheng,

Pamela C. Powell,

Greg Walcott,

Mustafa I. Ahmed,

Himanshu Gupta,

Ravi Desai,

ChihChang Wei,

Naoki Hase,

Tsunefumi Kobayashi,

Abdelkarim Sabri,

Henk Granzier,

Thomas S. Denney,

Michael Tillson,

A. Ray Dillon,

Ahsan Husain,

Louis J. Dell’Italia

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.921619

Subject(s) - fibronectin , myofibril , medicine , extracellular matrix , chymase , phosphorylation , endocrinology , cardiology , biology , microbiology and biotechnology , immunology , mast cell

The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix. In addition to profibrotic effects, chymase has significant antifibrotic actions because it activates matrix metalloproteinases and kallikrein and degrades fibronectin. Thus, we hypothesize that chymase inhibitor (CI) will attenuate extracellular matrix loss and LV remodeling in MR.

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