Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension | Zendy

Stephen L. Archer | Zendy; Glenn Marsboom | Zendy; Gene Kim | Zendy; Hannah J. Zhang | Zendy; Péter T. Tóth | Zendy; E. C. Svensson | Zendy; Jason R.B. Dyck | Zendy; Mardi GombergMaitland | Zendy; Bernard Thébaud | Zendy; Aliya N. Husain | Zendy; Nicole A. Cipriani | Zendy; Jalees Rehman | Zendy

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Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

Author(s) -

Stephen L. Archer,

Glenn Marsboom,

Gene Kim,

Hannah J. Zhang,

Péter T. Tóth,

E. C. Svensson,

Jason R.B. Dyck,

Mardi GombergMaitland,

Bernard Thébaud,

Aliya N. Husain,

Nicole A. Cipriani,

Jalees Rehman

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.916098

Subject(s) - medicine , superoxide dismutase , cardiology , superoxide , epigenetics , oxidative stress , biochemistry , enzyme , biology , gene

Excessive proliferation and impaired apoptosis of pulmonary artery (PA) smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn-hooded rats (FHRs) with PA hypertension (PAH). Expression and activity of mitochondrial superoxide dismutase-2 (SOD2), the major generator of H(2)O(2), is known to be reduced in PAH; however, the mechanism and therapeutic relevance of this are unknown.

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