The Yin and Yang of Cholesteryl Ester Transfer Protein in Cardiovascular Disease | Zendy

Prediman K. Shah | Zendy

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The Yin and Yang of Cholesteryl Ester Transfer Protein in Cardiovascular Disease

Author(s) -

Prediman K. Shah

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.910133

Subject(s) - medicine , cholesterylester transfer protein , disease , cardiology , cholesterol , lipoprotein

holesteryl ester transfer protein (CETP) is a 79-kDaglycoprotein, present in humans, rabbits, primates, andhamsters but absent in rodents, dogs, horses, cows, and pigs,that facilitates transfer of cholesteryl ester from high-densitylipoprotein (HDL) particles to low-density lipoprotein(LDL)–very-low-density lipoprotein (vLDL) particles in ex-change for triglycerides, thereby participating in reversecholesterol transport and regulating circulating HDL choles-terol (HDL-C) levels.

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