Nox Activator 1
Author(s) -
Xi-Lin Niu,
Nageswara R. Madamanchi,
Aleksandr E. Vendrov,
Igor Tchivilev,
Mauricio Rojas,
Chaitanya Madamanchi,
Ralf P. Brandes,
Karl-Heinz Krause,
Julia Humphries,
Alberto Smith,
K G Burnand,
Marschall S. Runge
Publication year - 2010
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.109.908319
Subject(s) - nadph oxidase , nox1 , vascular smooth muscle , activator (genetics) , p22phox , medicine , microbiology and biotechnology , protein kinase b , reactive oxygen species , signal transduction , pharmacology , biology , receptor , smooth muscle
Despite a concerted effort by many laboratories, the critical subunits that participate in vascular smooth muscle cell (VSMC) NADPH oxidase function have yet to be elucidated. Given the potential therapeutic importance of cell-specific inhibition of NADPH oxidase, we investigated the role of Nox activator 1 (NoxA1), a homolog of p67phox, in VSMC NADPH oxidase function and atherosclerosis.
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