Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury | Zendy

SangBing Ong | Zendy; Sapna Subrayan | Zendy; Shiang Y. Lim | Zendy; Derek M. Yellon | Zendy; Sean M. Davidson | Zendy; Derek J. Hausenloy | Zendy

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Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

Author(s) -

SangBing Ong,

Sapna Subrayan,

Shiang Y. Lim,

Derek M. Yellon,

Sean M. Davidson,

Derek J. Hausenloy

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.906610

Subject(s) - mitochondrial fission , mitochondrion , mitochondrial permeability transition pore , medicine , dnm1l , ischemia , mitochondrial fusion , reperfusion injury , microbiology and biotechnology , apoptosis , mitochondrial apoptosis induced channel , pharmacology , programmed cell death , biology , mitochondrial dna , cytochrome c , biochemistry , gene

Whether alterations in mitochondrial morphology affect the susceptibility of the heart to ischemia/reperfusion injury is unknown. We hypothesized that modulating mitochondrial morphology protects the heart against ischemia/reperfusion injury.

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