Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart | Zendy

Guangwu Wang | Zendy; Tariq Hamid | Zendy; Rachel J. Keith | Zendy; Guihua Zhou | Zendy; Charles Partridge | Zendy; Xilin Xiang | Zendy; Justin R. Kingery | Zendy; Robert K. Lewis | Zendy; Qianhong Li | Zendy; Gregg Rokosh | Zendy; Rachael Ford | Zendy; Francis G. Spinale | Zendy; Daniel W. Riggs | Zendy; Sanjay Srivastava | Zendy; Aruni Bhatnagar | Zendy; Roberto Bolli | Zendy; Sumanth D. Prabhu | Zendy

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Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart

Author(s) -

Guangwu Wang,

Tariq Hamid,

Rachel J. Keith,

Guihua Zhou,

Charles Partridge,

Xilin Xiang,

Justin R. Kingery,

Robert K. Lewis,

Qianhong Li,

Gregg Rokosh,

Rachael Ford,

Francis G. Spinale,

Daniel W. Riggs,

Sanjay Srivastava,

Aruni Bhatnagar,

Roberto Bolli,

Sumanth D. Prabhu

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.905471

Subject(s) - medicine , oxidative stress , heme oxygenase , heart failure , endocrinology , ventricular remodeling , fibrosis , ejection fraction , myocardial fibrosis , apoptosis , muscle hypertrophy , heme , chemistry , biochemistry , enzyme

Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in cardiac remodeling and chronic heart failure (HF) is unknown. We hypothesized that induction of HO-1 in HF alleviates pathological remodeling.

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