Cardiac Index Is Associated With Brain Aging | Zendy

Angela L. Jefferson | Zendy; Jayandra J. Himali | Zendy; Alexa S. Beiser | Zendy; Rhoda Au | Zendy; Joseph M. Massaro | Zendy; Sudha Seshadri | Zendy; Philimon Gona | Zendy; Carol J Salton | Zendy; Charles DeCarli | Zendy; Christopher J. O’Donnell | Zendy; Emelia J. Benjamin | Zendy; Philip A. Wolf | Zendy; Warren J. Manning | Zendy

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Cardiac Index Is Associated With Brain Aging

Author(s) -

Angela L. Jefferson,

Jayandra J. Himali,

Alexa S. Beiser,

Rhoda Au,

Joseph M. Massaro,

Sudha Seshadri,

Philimon Gona,

Carol J Salton,

Charles DeCarli,

Christopher J. O’Donnell,

Emelia J. Benjamin,

Philip A. Wolf,

Warren J. Manning

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.905091

Subject(s) - medicine , cardiology , cardiac function curve , neuropsychology , cardiac index , dementia , brain size , magnetic resonance imaging , disease , cardiac output , radiology , hemodynamics , heart failure , cognition , psychiatry

Cardiac dysfunction is associated with neuroanatomic and neuropsychological changes in aging adults with prevalent cardiovascular disease, theoretically because systemic hypoperfusion disrupts cerebral perfusion, contributing to subclinical brain injury. We hypothesized that cardiac function, as measured by cardiac index, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community.

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