Human Adult Vena Saphena Contains Perivascular Progenitor Cells Endowed With Clonogenic and Proangiogenic Potential | Zendy

Paola Campagnolo | Zendy; Daniela Cesselli | Zendy; Ayman Al Haj Zen | Zendy; Antonio Paolo Beltrami | Zendy; Nicolle Kränkel | Zendy; Rajesh Katare | Zendy; Gianni D. Angelini | Zendy; Costanza Emanueli | Zendy; Paolo Madeddu | Zendy

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Human Adult Vena Saphena Contains Perivascular Progenitor Cells Endowed With Clonogenic and Proangiogenic Potential

Author(s) -

Paola Campagnolo,

Daniela Cesselli,

Ayman Al Haj Zen,

Antonio Paolo Beltrami,

Nicolle Kränkel,

Rajesh Katare,

Gianni D. Angelini,

Costanza Emanueli,

Paolo Madeddu

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.899252

Subject(s) - progenitor cell , medicine , cd34 , cd31 , population , immunology , angiogenesis , bone marrow , endothelial stem cell , stem cell , cancer research , pathology , microbiology and biotechnology , biology , biochemistry , environmental health , in vitro

Clinical trials in ischemic patients showed the safety and benefit of autologous bone marrow progenitor cell transplantation. Non-bone marrow progenitor cells with proangiogenic capacities have been described, yet they remain clinically unexploited owing to their scarcity, difficulty of access, and low ex vivo expansibility. We investigated the presence, antigenic profile, expansion capacity, and proangiogenic potential of progenitor cells from the saphenous vein of patients undergoing coronary artery bypass surgery.

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