Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice | Zendy

Qizhou Lian | Zendy; Yuelin Zhang | Zendy; Jinqiu Zhang | Zendy; Hua Kun Zhang | Zendy; Xingang Wu | Zendy; Yang Zhang | Zendy; Francis Fu-Yuen Lam | Zendy; Sarang Kang | Zendy; JianChuan Xia | Zendy; Wing-Hong Lai | Zendy; Ka-Wing Au | Zendy; Y. Y. Chow | Zendy; ChungWah Siu | Zendy; Chuen Neng Lee | Zendy; HungFat Tse | Zendy

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Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice

Author(s) -

Qizhou Lian,

Yuelin Zhang,

Jinqiu Zhang,

Hua Kun Zhang,

Xingang Wu,

Yang Zhang,

Francis Fu-Yuen Lam,

Sarang Kang,

JianChuan Xia,

Wing-Hong Lai,

Ka-Wing Au,

Y. Y. Chow,

ChungWah Siu,

Chuen Neng Lee,

HungFat Tse

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.898312

Subject(s) - mesenchymal stem cell , induced pluripotent stem cell , medicine , stem cell , clinical uses of mesenchymal stem cells , stem cell transplantation for articular cartilage repair , regenerative medicine , stem cell therapy , regeneration (biology) , microbiology and biotechnology , cd146 , cell therapy , ischemia , bone marrow , cellular differentiation , cancer research , immunology , pathology , adult stem cell , biology , embryonic stem cell , cd34 , biochemistry , gene

Aging and aging-related disorders impair the survival and differentiation potential of bone marrow mesenchymal stem cells (MSCs) and limit their therapeutic efficacy. Induced pluripotent stem cells (iPSCs) may provide an alternative source of functional MSCs for tissue repair. This study aimed to generate and characterize human iPSC-derived MSCs and to investigate their biological function for the treatment of limb ischemia.

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