Adipocyte Modulation of High-Density Lipoprotein Cholesterol | Zendy

Yuzhen Zhang | Zendy; Fiona C. McGillicuddy | Zendy; Christine Hinkle | Zendy; Sean M. O’Neill | Zendy; Jane M. Glick | Zendy; George H. Rothblat | Zendy; Muredach P. Reilly | Zendy

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Adipocyte Modulation of High-Density Lipoprotein Cholesterol

Author(s) -

Yuzhen Zhang,

Fiona C. McGillicuddy,

Christine Hinkle,

Sean M. O’Neill,

Jane M. Glick,

George H. Rothblat,

Muredach P. Reilly

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.897330

Subject(s) - abca1 , abcg1 , endocrinology , medicine , cholesterol , adipocyte , reverse cholesterol transport , adipose tissue , atp binding cassette transporter 1 , high density lipoprotein , biology , lipoprotein , biochemistry , transporter , gene

Adipose harbors a large depot of free cholesterol. However, a role for adipose in cholesterol lipidation of high-density lipoprotein (HDL) in vivo is not established. We present the first evidence that adipocytes support transfer of cholesterol to HDL in vivo as well as in vitro and implicate ATP-binding cassette subfamily A member 1 (ABCA1) and scavenger receptor class B type I (SR-BI), but not ATP-binding cassette subfamily G member 1 (ABCG1), cholesterol transporters in this process.

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