Regulatory T Cells Protect Mice Against Coxsackievirus-Induced Myocarditis Through the Transforming Growth Factor β–Coxsackie-Adenovirus Receptor Pathway | Zendy

Yufang Shi | Zendy; Masahiro Fukuoka | Zendy; Guohua Li | Zendy; Youan Liu | Zendy; Manyin Chen | Zendy; Michael Konviser | Zendy; Xin Chen | Zendy; Mary Anne Opavsky | Zendy; Peter P. Liu | Zendy

Open Access

Regulatory T Cells Protect Mice Against Coxsackievirus-Induced Myocarditis Through the Transforming Growth Factor β–Coxsackie-Adenovirus Receptor Pathway

Author(s) -

Yufang Shi,

Masahiro Fukuoka,

Guohua Li,

Youan Liu,

Manyin Chen,

Michael Konviser,

Xin Chen,

Mary Anne Opavsky,

Peter P. Liu

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.893248

Subject(s) - coxsackievirus , myocarditis , adoptive cell transfer , medicine , immunology , immune system , viral myocarditis , transforming growth factor , virus , enterovirus , virology , t cell

Coxsackievirus B3 infection is an excellent model of human myocarditis and dilated cardiomyopathy. Cardiac injury is caused either by a direct cytopathic effect of the virus or through immune-mediated mechanisms. Regulatory T cells (Tregs) play an important role in the negative modulation of host immune responses and set the threshold of autoimmune activation. This study was designed to test the protective effects of Tregs and to determine the underlying mechanisms.

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