Histone Deacetylase 3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow | Zendy

Anna Zampetaki | Zendy; Lingfang Zeng | Zendy; Andriana Margariti | Zendy; Qingzhong Xiao | Zendy; Hongling Li | Zendy; Zhongyi Zhang | Zendy; Anna Pepe | Zendy; Gang Wang | Zendy; Ouassila Habi | Zendy; E DEFALCO | Zendy; Gillian Cockerill | Zendy; Justin C. Mason | Zendy; Yanhua Hu | Zendy; Qingbo Xu | Zendy

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Histone Deacetylase 3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow

Author(s) -

Anna Zampetaki,

Lingfang Zeng,

Andriana Margariti,

Qingzhong Xiao,

Hongling Li,

Zhongyi Zhang,

Anna Pepe,

Gang Wang,

Ouassila Habi,

E DEFALCO,

Gillian Cockerill,

Justin C. Mason,

Yanhua Hu,

Qingbo Xu

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.890491

Subject(s) - medicine , histone deacetylase , cancer research , histone , immunology , genetics , biology , gene

Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3 in preserving endothelial integrity in areas of disturbed blood flow, ie, bifurcation areas prone to atherosclerosis development.

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