Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform | Zendy

Sudarsan Rajan | Zendy; Ganapathy Jagatheesan | Zendy; Chehade N. Karam | Zendy; Marco Stephan LofranoAlves | Zendy; Ilona Bódi | Zendy; Arnold Schwartz | Zendy; Christian F. Bulcao | Zendy; Karen M. D’Souza | Zendy; Shahab A. Akhter | Zendy; Greg P. Boivin | Zendy; Dipak K. Dube | Zendy; Natalia Petrashevskaya | Zendy; Andrew B. Herr | Zendy; Roger Hullin | Zendy; Stephen B. Liggett | Zendy; Beata M. Wolska | Zendy; R. John Solaro | Zendy; David F. Wieczorek | Zendy

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Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform

Author(s) -

Sudarsan Rajan,

Ganapathy Jagatheesan,

Chehade N. Karam,

Marco Stephan LofranoAlves,

Ilona Bódi,

Arnold Schwartz,

Christian F. Bulcao,

Karen M. D’Souza,

Shahab A. Akhter,

Greg P. Boivin,

Dipak K. Dube,

Natalia Petrashevskaya,

Andrew B. Herr,

Roger Hullin,

Stephen B. Liggett,

Beata M. Wolska,

R. John Solaro,

David F. Wieczorek

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.889725

Subject(s) - myofilament , gene isoform , tropomyosin , myofibril , dilated cardiomyopathy , heart failure , medicine , cardiomyopathy , cardiac muscle , actin , genetically modified mouse , endocrinology , microbiology and biotechnology , transgene , myocyte , biology , biochemistry , gene

Tropomyosin (TM), an essential actin-binding protein, is central to the control of calcium-regulated striated muscle contraction. Although TPM1alpha (also called alpha-TM) is the predominant TM isoform in human hearts, the precise TM isoform composition remains unclear.

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