Molecular Magnetic Resonance Imaging of Myocardial Angiogenesis After Acute Myocardial Infarction | Zendy

M. van Oostendorp | Zendy; Kim Douma | Zendy; Allard Wagenaar | Zendy; Jos Slenter | Zendy; Tilman M. Hackeng | Zendy; Marc A. M. J. van Zandvoort | Zendy; Mark J. Post | Zendy; Walter H. Backes | Zendy

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Molecular Magnetic Resonance Imaging of Myocardial Angiogenesis After Acute Myocardial Infarction

Author(s) -

M. van Oostendorp,

Kim Douma,

Allard Wagenaar,

Jos Slenter,

Tilman M. Hackeng,

Marc A. M. J. van Zandvoort,

Mark J. Post,

Walter H. Backes

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.889451

Subject(s) - medicine , magnetic resonance imaging , myocardial infarction , angiogenesis , cardiac magnetic resonance , cardiology , cardiac magnetic resonance imaging , radiology

Angiogenesis is a natural mechanism to restore perfusion to the ischemic myocardium after acute myocardial infarction (MI). Therapeutic angiogenesis is being explored as a novel treatment for MI patients; however, sensitive, noninvasive in vivo measures of therapeutic efficacy are lacking and need to be developed. Here, a molecular magnetic resonance imaging method is presented to noninvasively image angiogenic activity in vivo in a murine model of MI with cyclic Asn-Gly-Arg (cNGR)-labeled paramagnetic quantum dots (pQDs). The tripeptide cNGR homes specifically to CD13, an aminopeptidase that is strongly upregulated during myocardial angiogenesis.

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