Noninvasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model | Zendy

Zhen Xu | Zendy; Gabe E. Owens | Zendy; David Gordon | Zendy; Charles A. Cain | Zendy; Achi Ludomirsky | Zendy

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Noninvasive Creation of an Atrial Septal Defect by Histotripsy in a Canine Model

Author(s) -

Zhen Xu,

Gabe E. Owens,

David Gordon,

Charles A. Cain,

Achi Ludomirsky

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.889071

Subject(s) - medicine , ultrasound , atrial septum , cardiology , ultrasonic sensor , radiology , biomedical engineering

The primary objective of this study was to develop an image-guided, noninvasive procedure to create or enlarge an atrial septal defect for the treatment of neonates with hypoplastic left heart syndrome and an intact or restrictive atrial septum. Histotripsy is an innovative ultrasonic technique that produces nonthermal, mechanical tissue fractionation through the use of high-intensity ultrasound pulses. This article reports the pilot in vivo study to create an atrial septal defect through the use of extracardiac application of histotripsy in an open-chest canine model.

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