Enhancement of Myocardial Regeneration Through Genetic Engineering of Cardiac Progenitor Cells Expressing Pim-1 Kinase | Zendy

Kimberlee M. Fischer | Zendy; Christopher T. Cottage | Zendy; Weitao Wu | Zendy; Shabana Din | Zendy; Natalie Gude | Zendy; Daniele Avitabile | Zendy; Pearl Quijada | Zendy; Brett Collins | Zendy; Jenna Fransioli | Zendy; Mark A. Sussman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Enhancement of Myocardial Regeneration Through Genetic Engineering of Cardiac Progenitor Cells Expressing Pim-1 Kinase

Author(s) -

Kimberlee M. Fischer,

Christopher T. Cottage,

Weitao Wu,

Shabana Din,

Natalie Gude,

Daniele Avitabile,

Pearl Quijada,

Brett Collins,

Jenna Fransioli,

Mark A. Sussman

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.884403

Subject(s) - medicine , regeneration (biology) , progenitor cell , stem cell , cancer research , ex vivo , in vivo , microbiology and biotechnology , immunology , biology

Despite numerous studies demonstrating the efficacy of cellular adoptive transfer for therapeutic myocardial regeneration, problems remain for donated cells with regard to survival, persistence, engraftment, and long-term benefits. This study redresses these concerns by enhancing the regenerative potential of adoptively transferred cardiac progenitor cells (CPCs) via genetic engineering to overexpress Pim-1, a cardioprotective kinase that enhances cell survival and proliferation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research