γ-H2AX Foci as a Biomarker for Patient X-Ray Exposure in Pediatric Cardiac Catheterization | Zendy

Laurence Beels | Zendy; Klaus Bacher | Zendy; Daniël De Wolf | Zendy; Joke Werbrouck | Zendy; Hubert Thierens | Zendy

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γ-H2AX Foci as a Biomarker for Patient X-Ray Exposure in Pediatric Cardiac Catheterization

Author(s) -

Laurence Beels,

Klaus Bacher,

Daniël De Wolf,

Joke Werbrouck,

Hubert Thierens

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.880385

Subject(s) - medicine , biomarker , population , cardiac catheterization , nuclear medicine , radiosensitivity , radiological weapon , radiology , radiation therapy , biochemistry , chemistry , environmental health

A better knowledge of patient x-ray dose and the associated radiation risk in pediatric interventional cardiology is warranted in view of the extensive use of x-rays and the higher radiosensitivity of children. In the present study, gamma-H2AX foci were used as a biomarker for radiation-induced effects. Patient-specific dose was assessed and radiation risks were estimated according to the linear-no-threshold model, commonly used in radiation protection, and the gamma-H2AX foci data.

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