NOS1AP Is a Genetic Modifier of the Long-QT Syndrome | Zendy

Lia Crotti | Zendy; Maria Cristina Monti | Zendy; Roberto Insolia | Zendy; Anna L. Peljto | Zendy; Althea Goosen | Zendy; Paul A. Brink | Zendy; David A. Greenberg | Zendy; Peter J. Schwartz | Zendy; Alfred L. George | Zendy

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NOS1AP Is a Genetic Modifier of the Long-QT Syndrome

Author(s) -

Lia Crotti,

Maria Cristina Monti,

Roberto Insolia,

Anna L. Peljto,

Althea Goosen,

Paul A. Brink,

David A. Greenberg,

Peter J. Schwartz,

Alfred L. George

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.879643

Subject(s) - qt interval , long qt syndrome , medicine , sudden cardiac death , population , sudden death , cardiology , environmental health

In congenital long-QT syndrome (LQTS), a genetically heterogeneous disorder that predisposes to sudden cardiac death, genetic factors other than the primary mutation may modify the probability of life-threatening events. Recent evidence indicates that common variants in NOS1AP are associated with the QT-interval duration in the general population.

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