Smooth Muscle Cells Orchestrate the Endothelial Cell Response to Flow and Injury | Zendy

Mercedes Balcells | Zendy; Jordi Martorell | Zendy; Carla Olivé | Zendy; Marı́a Santacana | Zendy; Vipul C. Chitalia | Zendy; Angelo A. Cardoso | Zendy; Elazer R. Edelman | Zendy

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Smooth Muscle Cells Orchestrate the Endothelial Cell Response to Flow and Injury

Author(s) -

Mercedes Balcells,

Jordi Martorell,

Carla Olivé,

Marı́a Santacana,

Vipul C. Chitalia,

Angelo A. Cardoso,

Elazer R. Edelman

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.877282

Subject(s) - medicine , microbiology and biotechnology , endothelial stem cell , in vitro , biology , biochemistry

Local modulation of vascular mammalian target of rapamycin (mTOR) signaling reduces smooth muscle cell (SMC) proliferation after endovascular interventions but may be associated with endothelial cell (EC) toxicity. The trilaminate vascular architecture juxtaposes ECs and SMCs to enable complex paracrine coregulation but shields SMCs from flow. We hypothesized that flow differentially affects mTOR signaling in ECs and SMCs and that SMCs regulate mTOR in ECs.

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