Open AccessAnalysis of Stroke in ATHENA: A Placebo-Controlled, Double-Blind, Parallel-Arm Trial to Assess the Efficacy of Dronedarone 400 mg BID for the Prevention of Cardiovascular Hospitalization or Death From Any Cause in Patients With Atrial Fibrillation/Atrial Flutter
Author(s) -
Stuart J. Connolly,
Harry J.G.M. Crijns,
Christian TorpPedersen,
Martin van Eickels,
Christophe Gaudin,
Richard L. Page,
Stefan H. Hohnloser
Publication year - 2009
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.109.875252
Subject(s) - medicine , dronedarone , atrial fibrillation , stroke (engine) , placebo , atrial flutter , cardiology , randomized controlled trial , hazard ratio , antithrombotic , anesthesia , confidence interval , amiodarone , mechanical engineering , alternative medicine , pathology , engineering
Many patients with atrial fibrillation are at high risk for stroke and require antithrombotic therapy. Antiarrhythmic drugs have not previously been shown to reduce the risk of stroke in atrial fibrillation. The effect of dronedarone, a new multichannel-blocking antiarrhythmic drug, on stroke has been evaluated in a randomized, double-blind clinical trial, ATHENA (A placebo-controlled, double-blind, parallel-arm Trial to assess the efficacy of dronedarone 400 mg BID for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation/atrial flutter).
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