Cholesteryl Ester Transfer Protein and Mortality in Patients Undergoing Coronary Angiography
Author(s) -
Andreas Ritsch,
Hubert Scharnagl,
Kathrin Eller,
Ivan Tancevski,
Kristina Duwensee,
Egon Demetz,
A. Sandhofer,
Bernhard O. Boehm,
Bernhard R. Winkelmann,
Josef R. Patsch,
Winfried März
Publication year - 2010
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.109.875013
Subject(s) - medicine , cholesterylester transfer protein , quartile , cardiology , coronary artery disease , hazard ratio , diabetes mellitus , lipoprotein , cholesterol , endocrinology , confidence interval
The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still open to debate. In the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial, inhibition of CETP in patients with high cardiovascular risk was associated with increased high-density lipoprotein levels but increased risk of cardiovascular morbidity and mortality. In this report, we present a prospective observational study of patients referred to coronary angiography in which CETP was examined in relation to morbidity and mortality.
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