Th17 and Th1 T-Cell Responses in Giant Cell Arteritis | Zendy

Jiusheng Deng | Zendy; Brian R. Younge | Zendy; Richard A. Olshen | Zendy; Jörg J. Goronzy | Zendy; Cornelia M. Weyand | Zendy

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Th17 and Th1 T-Cell Responses in Giant Cell Arteritis

Author(s) -

Jiusheng Deng,

Brian R. Younge,

Richard A. Olshen,

Jörg J. Goronzy,

Cornelia M. Weyand

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.872903

Subject(s) - medicine , giant cell arteritis , glucocorticoid , inflammation , immunology , flow cytometry , vasculitis , arteritis , systemic vasculitis , systemic inflammation , interferon , interleukin 17 , pathology , disease

In giant cell arteritis (GCA), vasculitic damage of the aorta and its branches is combined with a syndrome of intense systemic inflammation. Therapeutically, glucocorticoids remain the gold standard because they promptly and effectively suppress acute manifestations; however, they fail to eradicate vessel wall infiltrates. The effects of glucocorticoids on the systemic and vascular components of GCA are not understood.

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