Association of Circulating Cholesteryl Ester Transfer Protein Activity With Incidence of Cardiovascular Disease in the Community | Zendy

Ramachandran S. Vasan | Zendy; Michael Pencina | Zendy; Sander J. Robins | Zendy; Justin P. Zachariah | Zendy; Guneet Kaur | Zendy; Ralph B. D’Agostino | Zendy; José M. Ordovás | Zendy

Open Access

Association of Circulating Cholesteryl Ester Transfer Protein Activity With Incidence of Cardiovascular Disease in the Community

Author(s) -

Ramachandran S. Vasan,

Michael Pencina,

Sander J. Robins,

Justin P. Zachariah,

Guneet Kaur,

Ralph B. D’Agostino,

José M. Ordovás

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.109.872705

Subject(s) - medicine , cholesterylester transfer protein , hazard ratio , myocardial infarction , incidence (geometry) , framingham heart study , cardiology , confidence interval , cholesterol , heart failure , framingham risk score , stroke (engine) , lipoprotein , disease , mechanical engineering , physics , optics , engineering

Plasma high-density lipoprotein cholesterol concentration is related inversely to the risk of cardiovascular disease (CVD). Inhibiting cholesteryl ester transfer protein (CETP) activity raises high-density lipoprotein cholesterol and may be cardioprotective, but an initial clinical trial with a CETP inhibitor was stopped prematurely because of increased CVD in treated patients, raising concerns about this approach. Data relating circulating CETP concentrations to CVD incidence in the community are conflicting.

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